Gene Editing for Cosmecutical purposes must trump all efforts to ban the technology.

Researchers in Britain make moves to perform gene editing in humans:

The early rush to ban such use is going to fall by the wayside very quickly as governments realize that banning the technology for human use domestically will only put their people at a huge disadvantage going forward. 

As I have been explaining at my blog for years and explained in my chapter of The Future of Business

:CrispR Cas9 will make all sorts new industries possible that are focused on genetic modification of superficial (phenotype) traits that are "low hanging fruit" modifications. It heralds the "cosmecutical" industry as I like to call it. I've written on this subject for quite some time having prognosticated its emergence going back a decade.

Research teams all over the world are probably already at work (bolstered by entrepreneurs and business people who have come across these ideas) will require a few months to years of focused research identifying the important gene networks, characterizing their variation and then will strike "gold" in the form of gene editing mods to switch individual network pathways to desired output forms either somatically (which isn't permanent nor does it transfer to progeny) or germ line (which is both). 

The existing industry for cosmetics will flower with these new non invasive and extremely safe future means of effecting things like skin color change, hair color change, hair texture change and eye color change. Taken together I've researched that this industry is at least a trillion dollar potential. 

Beyond the money however I see it as mans final domination of much of the source of xenophobia in human society. It is based on identification of apparent physical difference and creating arbitrary distinctions of ability, merit and association from them...what happens when technology can truly turn a black person white or a white person black?

All sorts of awakenings happen in the social landscape. The coming together of humans of shared experience which the internet started, the web accelerated and mobile web kicked into high gear...will be boosted yet again when superficial markers become totally and completely a fashion choice...an accessory to wear and take off ...not a symbol of identity to fight and kill and oppress over. 

The dawn of the age of Neapolitan people:

http://sent2null.blogspot.com/2015/06/neopolitan-people-and-rachel-dolezal.html

The obfuscation, if not end of skin based privileges and the attendant evils that they have created and maintain in many parts of the world is nigh using such technology and for that alone it may be worth all the risks.

For me this is the greatest power in the unleashing of such technologies and why it is CRITICAL we let it happen no matter what short term consequences result ....and be sure some will, teams will make mistakes in their characterizing of various pathways....teams will not produce guide RNA that are specific enough in their identification of extant pathways and result in undesired modifications. 

If testing (likely in animal models) is not fully performed, these may impact the deployment of the technology in the first nations to go live with human tests; so it is important that during this research process that it is:

 a) visible to regulation and 
 b) complete to cover as many edge cases as possible.

Making such modifications illegal makes both a) impossible and b) unlikely (up to the ethical fiat of the "gene kiddies" running basement biolabs who would other wise be trying). So early embrace and control and guidance is the only rational choice for any government.

the attributes of web 3.0...

As the US economy continues to suffer the doldrums of stagnant investment in many industries, belt tightening budgets in many of the largest cities and continuous rounds of lay offs at some of the oldest of corporations, it is little comfort to those suffering through economic problems that what is happening now, has happened before. True, the severity of the downturn might have been different but the common factors of people and businesses being forced to do more with less is the theme of the times. Like environmental shocks to an ecosystem, stresses to the economic system lead to people hunkering down to last the storm, but it is instructive to realize that during the storm, all that idle time in the shelter affords people the ability to solve previous or existing problems. Likewise, economic downturns enable enterprising individuals and corporations the ability to make bold decisions with regard to marketing , sales or product focus that can lead to incredible gains as the economic

How many cofactors for inducing expression of every cell type?

Another revolution in iPSC technology announced: "Also known as iPS cells, these cells can become virtually any cell type in the human body -- just like embryonic stem cells. Then last year, Gladstone Senior Investigator Sheng Ding, PhD, announced that he had used a combination of small molecules and genetic factors to transform skin cells directly into neural stem cells. Today, Dr. Huang takes a new tack by using one genetic factor -- Sox2 -- to directly reprogram one cell type into another without reverting to the pluripotent state." -- So the method invented by Yamanaka is now refined to rely only 1 cofactor and b) directly generate the target cell type from the source cell type (skin to neuron) without the stem like intermediate stage. It also mentions that oncogenic triggering was eliminated in their testing. Now comparative methods can be used to discover other types...the question is..is Sox2 critical for all types? It may be that skin to neuron relies on Sox2

AgilEntity Architecture: Action Oriented Workflow

Permissions, fine grained versus management headache The usual method for determining which users can perform a given function on a given object in a managed system, employs providing those Users with specific access rights via the use of permissions. Often these permissions are also able to be granted to collections called Groups, to which Users are added. The combination of Permissions and Groups provides the ability to provide as atomic a dissemination of rights across the User space as possible. However, this granularity comes at the price of reduced efficiency for managing the created permissions and more importantly the Groups that collect Users designated to perform sets of actions. Essentially the Groups serve as access control lists in many systems, which for the variable and often changing environment of business applications means a need to constantly update the ACL’s (groups) in order to add or remove individuals based on their ability to perform cert

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